![]() ![]() By contrast, Type 2 MI, defined as myocardial injury with myocyte necrosis due to an acute ischemic imbalance between myocardial oxygen supply and/or demand without plaque disruption, has heterogeneous underlying causes (eg, coronary spasm, coronary endothelial dysfunction, arrhythmias, anemia, respiratory failure, shock, severe hypertension, or hypotension). 1 Notably, subtypes of Type 1 MI (ie, ST elevation MI and non-ST elevation MI ) share common pathophysiological mechanisms (typically spontaneous plaque rupture, ulceration, erosion, or dissection with thrombus formation resulting in myocyte necrosis), with extensive guidelines defining best clinical practice. Customer Service and Ordering InformationĪ generation of experimental and clinical research provides the pathophysiological construct for the classification of myocardial infarction (MI) described in the 2012 European Society of Cardiology/American College of Cardiology Foundation/American Heart Association/World Heart Federation Expert Consensus Document on the Third Universal Definition of Myocardial Infarction. ![]() ![]() Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB). ![]()
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